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Alienation is an isometric twin-stick shooter game set in a future in which aliens are invading Earth. After a large portion of the population has been murdered or mutated, humanity's fate rests with a group of four soldiers from UNX. The game features a single-player mode, a local co-op mode, and a multiplayer mode that allows four people to play at once, with each player controlling a heavily-modified soldier from one of three character classes: Bio-Specialist, Saboteur, and Tank. Each class has its own weapons, movement mechanics, and abilities, and can be "leveled up" to level thirty.